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LEARNING OBJECTIVES Use the following learning objectives to guide your reading and studying of the material for BIOL 2040. Ch. 14 – Chromosomal Rearrangements: After reading the assigned portions of Chapter 14 you should be able to: mutations (silent, missense, nonsense, frameshift) Describe the effects of a mutation outside the coding sequence of a gene on gene expression. Describe substitutions (including transitions and transversions); deletions; insertions, inversions, reciprocal translocations. Describe how chromosomal rearrangements could be studied. Describe why reversions are rare for deletions. Identify a mutagen that causes deletions. Describe the circumstances under which a deletion may be visible in a karyotype. Describe the chances of survival with a deletion. Describe why heterozygosity for a deletion may be very deleterious. Relate deletions to Knudson’s 2‐hit hypothesis. Describe how pseudodominance can be used to map a gene. Describe why deletion loops occur during meiosis of deletion heterozygotes. Describe polytene chromosomes and their use in genetics with respect to chromosomal rearrangements. Map genes and their deletions using deletion heterozygotes.
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This note was uploaded on 01/10/2010 for the course BIOLOGY biol2040 taught by Professor Tamarakelly during the Fall '09 term at York University.

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