Lecture 21. Thursday, November 16. Allostery and Hemoglobin.

Lecture 21. Thursday, November 16. Allostery and...

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Unformatted text preview: Restricted: For students enrolled in Chem130/MCB100A, UC Berkeley, Fall 2006 ONLY.Lecture 21 1 John Kuriyan: University of California, Berkeley Chem C130/MCB 100A, Fall 2006, Lecture 21 (November 16) Allostery In the last lecture we saw that if the binding curve for hemoglobin were hyperbolic, hemoglobin would be a poor transporter of oxygen. This is because the oxygen concentration [O 2 ] differs by only a factor of 3 between the tissues and the lungs. Instead, the biding curve is sigmoidal: Restricted: For students enrolled in Chem130/MCB100A, UC Berkeley, Fall 2006 ONLY.Lecture 21 2 In order to understand why the binding curve is sigmoidal, we consider a simple dimeric protein. Now let us analyze the consequence of allostery. The binding of the ligand causes a structural change in the protein The association constant for the second ligand molecule binding is different from the first one: Restricted: For students enrolled in Chem130/MCB100A, UC Berkeley, Fall 2006 ONLY.Lecture 21 2 In order to understand why the binding curve is sigmoidal, we consider a simple dimeric protein. Now let us analyze the consequence of allostery. The binding of the ligand causes a structural change in the protein The association constant for the second ligand molecule binding is different from the first one: Restricted: For students enrolled in Chem130/MCB100A, UC Berkeley, Fall 2006 ONLY.Lecture 21 3 At low concentration of ligand ([O 2 ]) the binding equilibrium is governed by K A1 (or K D1 ), of the T state....
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This note was uploaded on 01/12/2010 for the course MCB 100A taught by Professor Kuryian during the Fall '09 term at University of California, Berkeley.

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Lecture 21. Thursday, November 16. Allostery and...

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