5-lipids-memb - Problem Set 5 Lipids/Membranes 1....

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Problem Set 5 Lipids/Membranes 1. Botulinum toxin is a multisubunit protein secreted by pathogenic strains of the bacterium, Clostridium botulinum, and is known to bind to a specific ganglioside, GT1B, on the surface of mammalian cells. ( a ) Describe the general structure of any ganglioside. (Model your answer after the following description of a nucleotide: “ purine or pyrimidine base, attached to the sugar ribose, with a phosphate group on the ribose.”) As part of your answer, please also include a diagram that shows how these components are connected (bonded) to each other. ( b ) Describe what happens when gangliosides and glycerophospholipids are mixed together in an aqueous solution. In addition, explain your answer in terms of how and why the structures of these molecules contribute to what happens. 2. One portion of an integral membrane protein of interest is thought to be an α helix. ( a ) What structural features would you expect to be present in this α -helical segment if the helix constituted one element of a pore formed by several transmembrane helices? ( b ) What structural features would you expect to be present in this α -helical segment if its function were simply to allow the protein to span the lipid bilayer of a cellular membrane in the absence of any association with other transmembrane proteins? ( c
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This note was uploaded on 01/12/2010 for the course MCB 100B taught by Professor Alper/calendar during the Fall '08 term at University of California, Berkeley.

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5-lipids-memb - Problem Set 5 Lipids/Membranes 1....

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