Lecture14 - Complex III IV Substrate level phosphorylation Electron Transport Chain The Proton Gradient 1 H o w a re p ro to n s p u m p ed 2 W h a

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ΙΙΙ
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Complex III
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IV
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ΙΙ
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Substrate level phosphorylation
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The Proton Gradient
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1. How are protons pumped 2. What is the nature of the gradient/energetics 3. How many protons are pumped 4. How is the gradient maintained 5. How do the protons return to the matrix 6. How is that return coupled to ATP synthesis 7. How many ATP are produced per electron pair 8. How can the system be inhibited/studied
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Each carrier a stronger oxidizing agent-- Each step, negative free energy-- Complex I -18kcal/mole Complex II - 4kcal/mole Complex III -10kcal/mole Complex IV -27kcal/mole
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ADP + Pi ATP Η + Η + Η + Η + Η + Η +
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1. How are protons pumped 2. What is the nature of the gradient/energetics 3. How many protons are pumped 4. How is the gradient maintained 5. How do the protons return to the matrix 6. How is that return coupled to ATP synthesis 7. How many ATP are produced per electron pair 8. How can the system be inhibited/studied
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NADH FADH 2 CoQH 2 H 2 O
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1. How are protons pumped 2. What is the nature of the gradient/energetics 3. How many protons are pumped
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This note was uploaded on 01/12/2010 for the course MCB 100B taught by Professor Alper/calendar during the Fall '08 term at University of California, Berkeley.

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Lecture14 - Complex III IV Substrate level phosphorylation Electron Transport Chain The Proton Gradient 1 H o w a re p ro to n s p u m p ed 2 W h a

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