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14 regul - Can I go backwards-and make glucose...

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Can I go backwards--- and make glucose
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Gluconeogenesis
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Δ G<0 Δ G<0 Δ G<0
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Glu Pyr AcCoA Glycolysis ATP+CO 2 Krebs
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Metabolic Choices •Glycolysis vs gluconeogenesis •Krebs vs glyoxylate •Glycolysis vs hexose shunt •Pyruvate/PEP to anaplerotic vs Krebs •CO 2 and ATP vs biosynthesis •Lactate vs Ethanol vs Krebs
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Pyruvate Alanine OAA Malate Acetyl CoA Lactate Acetaldehyde
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Regulation • Sense cellular environment -which nutrients are present -Pasteur see glucose use up during anaerobic growth
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Regulation • Sense cellular environment • Balance conflicting needs growth energy
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Regulation • Sense cellular environment • Balance conflicting needs • Control activity of enzymes
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• Make/not make more or less enzyme • Control degradation • Zymogen activation • Alter enzyme to activate/inactivate Regulation of Enzyme Activity
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• “Equilibrium” non-covalent binding -small molecule -protein subunit • Covalent Modification Activation/Inactivation of Enzyme
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Equilibrium Modification Activation or inhibition • Active site or allosteric site • Cooperative or non-cooperative
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Where in pathway do we regulate?
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