XM2finalkey-1

XM2finalkey-1 - MCB 100B Spring 2007 Midterm 2 Key 4. (10...

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MCB 100B Spring 2007 Midterm 2 Key 4. (10 points) Inhibitors of metabolic pathways often block the action of an enzyme and lead to the increase in concentration of the material which is acted upon by that enzyme. Thus, for example, presence of an inhibitor of aldolase would lead to an accumulation of fructose-1,6-bis phosphate. a. Name three materials that begin to accumulate as a direct result of the use of oligomycin, an inhibitor of ATP synthase. Explain your answer. H+ outside the membrane—Protons cannot flow through the enzyme from the intermembrane space to the matrix; thus they accumulate outside. ADP--the enzyme is inhibited thus its substrate accumulates Pi—the enzyme is inhibited thus its substrate accumulates b. A student noticed that the total amount of NAD and NADH (summed) did not increase when rotenone was used to inhibit Complex I in electron transport. Explain. Electron transport is not a pathway in the sense of molecule A being converted to molecule B. Each carrier simply picks up and then delivers electrons, thus the total of the oxidized and reduced forms remains constant, equal to the total amount of the
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This note was uploaded on 01/12/2010 for the course MCB 100B taught by Professor Alper/calendar during the Spring '08 term at Berkeley.

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XM2finalkey-1 - MCB 100B Spring 2007 Midterm 2 Key 4. (10...

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