Lecture 12 ENGR 305 protein synthesis

Lecture 12 ENGR 305 protein synthesis - ENGR 305 Lecture 12...

Info iconThis preview shows pages 1–12. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: ENGR 305 Lecture 12 RNAi Yet another way to control mRNA (Nobel Prize 2 years ago) QuickTime and a TIFF (LZW) decompressor are needed to see this picture. microRNA vs. siRNA Micro RNAs are endogenous to cells Antisense technology Sense strand is coding mRNA is sense Complement of mRNA is antisense Idea is to put in an DNA (or RNA or other modified nucleic acid) that binds to the mRNA Binding to the mRNA blocks translation Sidebar X-ray crystallography allows us to determine the molecular structure of proteins, nucleic acids, and complexes Virtually no molecular weight limit on this (ribosome = 2.5 megadalton) Seemingly defeats Heisenberg Key is an ordered lattice of the object Synchrotron is also key for this process (intense, collimated, short controllable wavelength) Sidebar 2 Electron microscopy is also very powerful Does not yet give atomic resolution images (best are 9-15 resolution) Images collected in vitreous ice Information can be merged with X-ray data Translation (contd)...
View Full Document

Page1 / 70

Lecture 12 ENGR 305 protein synthesis - ENGR 305 Lecture 12...

This preview shows document pages 1 - 12. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online