Lecture 15 Protein interactions

Lecture 15 Protein interactions - Lecture 15 Molecular...

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Unformatted text preview: Lecture 15 Molecular Interactions Two papers Lancet D, Sadovsky E, Seidemann E. 1993. Probability model for molecular recognition in biological receptor repertiores: Significance to the Olfactory system. Proc. Natl. Acad. Sci. USA 90: 3715-9 Chakrabarti P, Janin J. 2002. Dissecting protein- protein recognition sites. Proteins 47: 334-43 Both papers PDFs Why is high complexity good? Intuitive feel that if you have more different molecules, this will make finding a binder better Key concept--binding is not a digital process--yes or no How tight does something bind? Binding affinity continued Even non-binders may bind to some degree Binding is driven by Hydrophobic effect (removal of water from hydrophobic surfaces Electrostatics + / - interactions H-bonds (really electrostatic in character) VdW (induced dipole-induced dipole) Even randomly chosen molecule has some affinity from these effects Hydrophobic Effect O H H 104.5 + - + O H H O H H + + + + - - Hydrophobic Surface Hydrophobic Surface + 3H 2 O Electrostatics...
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Lecture 15 Protein interactions - Lecture 15 Molecular...

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