ProblemSet7-1 - molecules of glucose to be transported into...

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BMB100B Winter 2009 Rubin Problem Set #7 It is not required that you turn this problem set in. 1) Ligands that bind to and affect function of G-protein coupled receptors are often described as agonists, inverse agonists, or antagonists. Define each of these terms and find examples of physiological ligands or drug compounds that fit each category. What are the receptors that your examples bind and what are the functions of those receptors? If known, describe how each ligand interacts with its receptor. 2) How much free energy is “stored” in a 10,000-fold concentration gradient? 3) Voet and Voet Ch. 20, Problem 7 (page 764) 4) In class it was mentioned that the membrane permeability coefficient for glucose has been measured to be 2x10 -4 cm/sec for a red blood cell. How long would it take for 10,000
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Unformatted text preview: molecules of glucose to be transported into the cell? Assume the diameter of a red blood cell is 8 µm, and the concentration gradient ([A] out – [A] in ) remains constant at 1 μ M. 5) Sketch a plot of J glucose as a function of [glucose] in the presence of the GLUT1 glucose transporter. Sketch a new plot and describe how the plot has changed in the following circumstances a) doubling the [GLUT1] concentration b) addition of a molecule that interacts with the glucose-binding site c) addition of a molecule that prevents the T1 T2 conformational change 6) Explain why it is critical that the lactose permease only interconvert between the E1 and E2 conformations when either both or neither of the ligands are bound. What is the similar safeguard mechanism in the Na-K ATPase?...
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