3Yeast: 12 Mb genome encodes ~5000 genes: gene/2.4kbHuman: 3,300 Mb genome encodes ~25,000 genes: gene/132 kb For example, there are 5 structure genes in this 80 kb human genome region, in contrast to 48 ORF in a 80 kb region of the yeast genome. Different organisms have different gene density
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4Comparison of the Chromosomal Gene Density in the Genomes of Different OrganismsConclusions:•Bacterial genomes have densely packed protein-coding genes, with minimal non-coding DNA sequences•Gene density decreases with increased biological complexity in eukaryotes•Protein-coding genes of higher eukaryotes have more and larger introns than lower eukaryotes•Amount of intron sequences (non-coding transcribed DNA) increases with biological complexity in higher eukaryotesGenesRepetitiveDNATwo types of genomic DNA