12_Endocytosis

12_Endocytosis - Transmembrane transport of macromolecules...

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1 Transport of macromolecules and particles across a membrane is mediated through a distinct process called endocytosis . Endocytosis Phagocytosis (a constitutive process for uptaking solid particles) Pinocytosis (a constitutive process for uptaking solutions) Clathrin-dependent endocytosis (via clathrin coated pits) Caveolin-dependent endocytosis (via caveolin coated pits called caveolae) Others Transmembrane transport of macromolecules and nanoparticles Doherty and McMahon, Annu. Rev. Biochem. 2009. 78:857–902 (Phagocytosis) (Clathrin-dependent endocytosis)
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2 Sorkin and von Zastrow, Nature Review: Molecular cell Biology, 2009 Signal Regulation during Endocytosis Sorkin and von Zastrow, Nature Review: Molecular cell Biology, 2009 Y receptor recycling or exocytosis coated pit clatherin ligand coated vesicle uncoating process early endosome late endosome lysosome from the nucleus receptor synthesis Modeling Clathrin-Dependent Endocytosis pinocytosis
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3 A Simplified Model for Receptor-Mediated Endocytosis of Ligands Y k rec coated pit ligand endosome lysosome from the nucleus V S k P k iR k + k deg k iC Definition of Concentrations N = number of molecules per cell C = molar concentration in the solution n = number of cells / volume of solution C = nN/N A (N A is the Avogadro’s number) 1. On the membrane, the processes include ligand binding to its receptor, diffusion of receptors, and
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This note was uploaded on 01/17/2010 for the course BME 100 taught by Professor Yuan during the Fall '07 term at Duke.

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12_Endocytosis - Transmembrane transport of macromolecules...

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