100Final%20conclusions

100Final%20conclusions - Modeling Molecular and Cellular...

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1 Modeling Molecular and Cellular systems Modeling Nature’s laws - 1 st law - 2 nd law - Mass conservation Experimental data - Model constants - Estalishing new relationships - Verify model predictions - Establish empirical Eqn in the model Hypotheses - e.g., law of mass action in this course What is covered in this course? Where to go from here? 1. Rates and kinetics of chemical reactions 2. Simplification of kinetic analysis 3. Enzyme kinetics and its regulation 4. Cell signaling 5. Cell growth kinetics 6. Regulation of gene expression 7. First and second laws of thermodynamics 8. Phase transition of pure substances 9. Standard State and Gibbs Energy 10. Simple mixtures 11. Chemical Equilibrium 12. Equilibrium DNA binding analysis 13. Receptor-mediated endocytosis Biological Systems at Multiple Scales Organ level (L = 10 -3 – 10 -1 m) Body level (L = 1 m) Tissue and Cell levels (L = 10 -5 – 10 -4 m) Molecular level (L = 10 -9 – 10 -7 m)
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