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BME%20100_2009%20ver2

BME%20100_2009%20ver2 - BME 100L Modeling Cellular and...

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BME 100L. Modeling Cellular and Molecular Systems Fall 2009 Lecture: M W 8:30 am to 9:45 am in Hudson 208 Lab Section 01L: M, 1:15 pm – 3:15 pm, Teer P013 02L: M, 4:25 pm – 6:25 pm, Teer P013 This course is an introduction to mathematical modeling of kinetic processes in cellular and molecular systems. It also discusses applications of these models in biotechnology. The topics include: thermodynamics, chemical equilibrium and kinetics, enzyme kinetics, DNA denaturation and rebinding, receptor-ligand binding, regulation of gene expression, and receptor- mediated endocytosis. Laboratory experiments are also included to help learn the concepts in the class. Prerequisites: Mathematics 103 and Biology 25 or equivalent. Course Outcomes: 1. Calculate changes of state variables (e.g., H, S, G) of pure, closed system (e.g., ideal gases and ideal solutions) at any temperature 2. Calculate changes of state variables (e.g., H, S, G) for mixing and chemical reactions 3. Perform kinetic analysis of simple reaction networks in biological systems 4. Use quasi-steady and quasi-equilibrium concepts to simplify kinetic models 5. Develop kinetic models of molecular events in cells based on known mechanisms 6.
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