CP3_Endocytosis

CP3_Endocytosis - BME 100L. Modeling Cellular and Molecular...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
BME 100L. Modeling Cellular and Molecular Systems Fall 2009 Project 3. Receptor-Mediated Endocytosis of EGF (Due: 5pm, December 2 th ) Epidermal growth factor (EGF) can stimulate the growth of different cells through binding to its receptor on the cell membrane. In this project, you will use a simplified kinetic model of EGF receptor-mediated endocytosis to explore the dynamics of EGF and its receptor in cells. The mass balance of ligand (i.e., EGF) requires that:  i L L rec C R L A c L N f k N k N C k N n dt dC 1 1 1 (1) where n c is the number of cells per unit volume of solution and N A is the Avogadro’s number. The mass balances of receptor and receptor-ligand complex on the cell surface as well as intracellular receptor and intracellular ligand require that: Surface receptor dN R dt  k 1 C L N R k 1 N C k eR N R k rec 1 f R N R i V s (2) Surface complex dN C dt k 1 C L N R k 1 k eC N C (3) Intracellular receptor dN R i dt k eR N R k eC N C k deg f R k rec 1 f R N R i (4) Intracellular ligand dN L i dt k eC N C k deg L f L k rec 1 f L N L i (5) where N is concentration with the unit being number of molecules per cell. Baseline
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 3

CP3_Endocytosis - BME 100L. Modeling Cellular and Molecular...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online