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Unformatted text preview: Name: __________________________________ Score _________________ BME 100L Fall 2007 Final Exam 1. Glucose metabolism in a low O 2 (i.e., hypoxic) environment involves the following reaction Fructose-1,6-diphosphate (FDP) dihydroxyacetone (DHAP) + Glyceraldehyde-3-phosphate (G3P)with r G = 23.8 kJ/mol. In a hypoxic red blood cell, pH = 7.4, [FDP] = 35 M, [DHAP] = 130 M, and [G3P] = 15 M. Can this reaction occur spontaneously in the cell? Explain why. Solution: This is a reaction in dilute solution, in which Z r r Q ln RT G G = 23.8 + 8.314*298*ln(15*130*10-6 /35) = 23.8 – 24.3 = -0.47 kJ/mol This reaction can occur spontaneously since r G < 0 . 2. Monoclonal antibodies (B) have been used to target tumor-associated antigens (A) in cancer diagnosis and treatment. Antibodies produced by B lymphocytes have two identical binding sites. Assume both sites bind to the antigen simultaneously in the following elementary reaction, B + 2A BA 2 k f k r At t = 0, antibody and antigen are mixed together in a solution. Initially, [A] = [A] , [B] = [B] , and there is no BA 2 . k f , k r , [A] , and [B] are constants....
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This note was uploaded on 01/17/2010 for the course BME 100 taught by Professor Yuan during the Fall '07 term at Duke.
- Fall '07