BIS104 Slide4 - Lecture 4 1. Membrane proteins and...

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Lecture 4 1. Membrane proteins and transport 2. Protein and lipid trafficking
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1-6 integral membrane proteins 7 & 8 peripherial membrane proteins Figure 10-19 Molecular Biology of the Cell Proteins associate with membrane in different ways
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-via a covalently attached fatty acid -by linkage to g lycosyl phosp hatidyli nositol (GPI anchor) -via noncovalent association Figure 10-19 Molecular Biology of the Cell (© Garland Science 2008) Proteins associate with membrane in different ways
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Figure 10-27 Molecular Biology of the Cell (© Garland Science 2008) Covalently joined sugars -protective -cell-cell recognition P
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Figure 10-35 Molecular Biology of the Cell (© Garland Science 2008) Similar to membrane lipids, Membrane proteins : -distribute asymmetrically in membrane -can diffuse lateral in the membrane -can rotate but rarely flip-flop
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Figure 10-37 Molecular Biology of the Cell (© Garland Science 2008) Ways to confine proteins/lipids to specific domains of a membrane -tight junction
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Self-assemble to large aggregates Tethered by specific macromolecules -extracellular matrix or intracellular cytoskeleton or both Interaction with proteins on the surface of another cell Figure 10-39 Molecular Biology of the Cell (© Garland Science 2008)
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Examples of what membrane proteins do 1. Connections to other cells or to extra-cellular matrix 2. Communication with other cells 3. Signal transduction (polypeptide hormone receptors) 4. Protective function (variable surface antigens of trypanosomes) 5. Transport
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Membranes are effective barriers to most water soluble molecules -via transmembrane diffusion -via specialized transporter proteins Metabolites, nutrients Wastes, extracellular proteins etc
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Figure 11-1 Molecular Biology of the Cell (© Garland Science 2008) Trans-membrane diffusion Relative permeability Facilitated transport required
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Figure 11-3a Molecular Biology of the Cell (© Garland Science 2008) Facilitated transport Faster but less specific Undergo conformational changes
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Figure 11-4a Molecular Biology of the Cell (© Garland Science 2008) Passive vs active transport
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Figure 11-8 Molecular Biology of the Cell (© Garland Science 2008) Three types of transporter mediated movement active Passive or Active
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Three ways of driving active transport Figure 11-7 Molecular Biology of the Cell (© Garland Science 2008)
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Figure 11-12 Molecular Biology of the Cell (© Garland Science 2008) Three types of ATP-driven pumps P: phosphorylated Pump ions F: F 0 /F 1 ATP synthase V: vacuolar H + pump Pump H + ABC: ATP binding cassette metabolites, drugs
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Role of active transport in addition to transporting metabolite -Transport Ca 2+ (signaling molecule in fertilization and muscle contraction) Figure 11-13b Molecular Biology of the Cell (© Garland Science 2008) - an example of the P-type ATPase (ATP-driven pump)
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This note was uploaded on 01/18/2010 for the course BIO SCI 104 taught by Professor Lin during the Spring '09 term at UC Davis.

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BIS104 Slide4 - Lecture 4 1. Membrane proteins and...

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