Lec1_Jan-4-2010_Ernest

Lec1_Jan-4-2010_Ernest - Welcome to Introduction to Applied...

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Unformatted text preview: Welcome to Introduction to Applied Ecological Genetics Genetics for Ecology, Health, and Conservation of Natural Populations ECL 242 / PHR 242 Instructor: Holly Ernest DVM PhD Mon and Wed 2:10-4pm Todays Lineup January 4, 2009 Introduction to the course Course mechanics History of Ecological Genetics and Introduction to Molecular Markers for Ecology Origin of a Cancer in Tasmanian Devils Devil facial tumor disease (DFTD) Transmissible cancer Affecting the Tasmanian devil ( Sarcophilus harrisii ), an endemic Tasmanian marsupial carnivore. First observed 1996 in northeastern Tasmania, Implicated in devil population collapse. Rapidly fatal disease that culminates in large tumors, primarily on the face and mouth, which frequently metastasize to internal organs. There are no diagnostic tests, treatments, or vaccines available for DFTD, and models predict that the disease could lead to extinction of wild Tasmanian devils within 25 to 35 years Torsten Blackwood/Agence France-Presse - Getty Images Scientists Discover Origin of a Cancer in Tasmanian Devils The Tasmanian Devil Transcriptome Reveals Schwann Cell Origins of a Clonally Transmissible Cancer Murchison et al. Science Jan 2010 DOI: 10.1126/science.1180616 Torsten Blackwood/Agence France-Presse - Getty Images http://dx.doi.org/10.1126/scienc e.1180616 http://www.nytimes.com/2010/ 01/01/science/01devil.html?hpw Ecological Genetics Interface of ecology, evolution, and genetics Genetics of ecologically important traits What are some traits? One of many aspects : Change in mean/variance of a trait across generations due to changes in allele frequencies Anyone know the name of this field? Today we often think Molecular (like in MOLECULAR ECOLOGY ) But Non-molecular genetics too What are some? Anything inherited can potentially act as a useful genetic character. Phenotypic / morphologic traits Behavioral traits What species is it? Resolve taxonomic uncertainties Morphologically indistinct species Identify species, subspecies, hybrid zones, populations Salt marsh harvest mouse Western Harvest Mouse Courtesy Sarah Brown April 2004 Toxic Diesel Fuel Pipe Leak 60,000 Gallons into Suisun Marsh California 242 acres affected Many birds & mammals killed Close-up of diesel fuel in water MtDNA Cytochrome b Sequencing Salt Marsh Harvest Mouse Western Harvest Mouse Courtesy, Sarah Brown and Francis Villablanca, Cal Poly What sex is it? Sexually monomorphic Certain birds including raptors Swainsons Hawk nestling Sac Bee Paul Kitaqaki photos Don Preisler Swainsons Hawk DNA Sex Markers Female is heterogametic sex: ZW Birds are opposite of mammals Males ZZ 2 conserved CHD (chromo-helicase-DNA-binding) genes located on avian sex chromosomes Genetic Markers Who are its parents and relatives?Who are its parents and relatives?...
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Lec1_Jan-4-2010_Ernest - Welcome to Introduction to Applied...

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