Note1 - Lecture 1 S. Harmer MCB 161 Molecular biology and...

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Lecture 1 MCB 161 S. Harmer Molecular biology and personal genomics – 1/05/10 Reading: Watson text: review chapters 1 and 2; plus pp 137-144; 762 – 764; also read the two brief news articles on medical genomics and an introduction to SNPs and association mapping (see the ‘Assigned Reading’ web page for these links). Problems: See web site. I. Basic vocabulary (review) Molecular genetics, central dogma, codons, open reading frames (ORFs), exons, introns, gene splicing, haploid, diploid, recessive, dominant II. Gene density varies between organisms A. E.coli has ~ 950 genes/megabase; humans only ~8.5 genes/megabase B. Large genomes tend to contain lots of repetitive and non-coding DNA (~5% of human genome evolutionarily conserved; rest “junk DNA” ???) III. Genome sequencing projects A. Exponential increase in sequence information in GenBank B. Sequences of whole genomes facilitates: i. Finding new genes ii. Determining how genes are regulated iii. Understanding how genome works as a whole
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Note1 - Lecture 1 S. Harmer MCB 161 Molecular biology and...

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