Problem1 - when you realize that since a member of the...

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MCB 161 Study Problems Lecture 1: Molecular biology and personal genomics 1. The genomes of ‘higher’ eukaryotes such as mammals and angiosperms are organized differently than those of ‘lower’ eukaryotes such as budding yeast ( Saccharomyces cerevisiae ). List 4 differences that contribute to the observed much lower gene density in humans than in yeast. a. b. c. d. 2. Look at the below pedigree showing the occurrence of a disease within a family. How would you characterize the inheritance of this disease? Indicate the presumptive genotype of each individual (i.e. +/ + = wild-type; +/- = heterozygous, -/- = homozygous mutant). Assume the disease phenotype is completely penetrant. 1. 2. 3. 4. 5. 6. 7. 8. 9. 3. You just had SNP analysis carried out by 23andMe. Your genome report tells you that you have a particular SNP that increases your risk of developing Giedt disease by 50% relative to the general population! At first, this terrifies you. Later, you calm down
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Unformatted text preview: when you realize that since a member of the general population has about a 1% risk of developing Giedt disease, your risk is estimated to be: 4. Explain why association studies, rather than traditional pedigree analysis, are most effective in identifying genomic regions and genes involved in common diseases. 5. In a recent news article, Dana Waring of the Personal Genetics Education Project was reported to say "Genetics is not destiny”. What did she mean by this? 6. Watch the ‘Technology Demo’ movie at the Pacific Biosciences web site ( ; see the lower right-hand corner) and then answer the following questions. Why is there fluorescence detected when the correct new base is being incorporated into the growing DNA strand? How can the researchers discriminate between the 4 different bases? Once this technology is more affordable, why will this be better than the current SNP tests such as the one marketed by 23andMe?...
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This note was uploaded on 01/18/2010 for the course BIO SCI 104 taught by Professor Lin during the Spring '09 term at UC Davis.

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Problem1 - when you realize that since a member of the...

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