Answer1 - MCB 161 Lecture 1 Molecular biology and personal genomics Study Problems 1 The genomes of higher eukaryotes such as mammals and

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MCB 161 Study Problems Lecture 1: Molecular biology and personal genomics 1. The genomes of ‘higher’ eukaryotes such as mammals and angiosperms are organized differently than those of ‘lower’ eukaryotes such as budding yeast (Saccharomyces cerevisiae). List 4 differences that contribute to the observed much lower gene density in humans than in yeast. a. smaller exons b. more introns c. larger intergenic regions d. more repeated sequences (such as transposons) 2. Look at the below pedigree showing the occurrence of a disease within a family. How would you characterize the inheritance of this disease? Type of disease: Recessive Indicate the presumptive genotype of each individual (i.e. +/ + = wild-type; +/- = heterozygous, -/- = homozygous mutant). Assume the disease phenotype is completely penetrant. 1. +/- 2. +/- 3. +/? 4. -/- 5. +/- 6. +/- 7. +/- 8. +/- 9. -/- 3. You just had SNP analysis carried out by 23andMe. Your genome report tells you that you have a particular SNP that increases your risk of developing Giedt disease by 50% relative to the general population! At first, this terrifies you. Later, you calm down when you realize that since a member of the general population has about a 1% risk of
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This note was uploaded on 01/18/2010 for the course BIO SCI 104 taught by Professor Lin during the Spring '09 term at UC Davis.

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Answer1 - MCB 161 Lecture 1 Molecular biology and personal genomics Study Problems 1 The genomes of higher eukaryotes such as mammals and

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