Lecture 16 - POST LECTURE Hematopoiesis.pptx - Hematopoiesis Dr Anshu Kacker 2 3 Objectives \u2022 Recognize the features with the yolk-sac hepatic and

Lecture 16 - POST LECTURE Hematopoiesis.pptx -...

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Hematopoiesis Dr. Anshu Kacker
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Objectives Recognize the features with the yolk-sac, hepatic and bone marrow phases of hemopoiesis. Identify the sequences of changes in size, color, and chromatin pattern common to all maturing blood cells. Differentiate between erythrocytic, agranulocytic and granulocytic precursor cells in bone marrow. Cite examples of the lineages of RBCs and WBCs as found in bone marrow. Analyze phagocytic cells in blood as to their origins, sites of phagocytosis and roles in health and disease. Describe the lineage, development and maturation of megakaryocytes and platelet Describe both light and electron microscopic histology of the formed elements of circulating blood. List the temporary sites of blood development in the adult human. 4
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Hematopoiesis Formation of blood cells - erythropoiesis, leukopoiesis, thrombopoiesis. Production and destruction of blood an ongoing process relatively constant number of cell types maintained in circulation. RBCs and Platelets: entire life spent in circulation. Leukocytes: leave blood; live and function in tissues. 5
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Hematopoiesis In fetus, red & white cells formed in several organs (before bone marrow is formed). 1st / yolk-sac phase Begins 3rd week of gestation. Blood islands form in the mesoderm of the yolk sac. 6
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Hematopoiesis 2nd / hepatic phase Hemopoietic centers appear in the liver. During the 2nd trimester the liver is the major blood forming organ in the fetus. Declines during the fifth month. Spleen produces mainly erythrocytes and small no. of granulocytes and platelets. 7 Liver without hematopoiesis
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Hemopoiesis 3rd / bone marrow phase Bone marrow (and other lymphoid tissue involved). Begins during 2nd trimester of pregnancy. After birth hematopoiesis takes place in red bone marrow and lymphoid tissues. 8 Bone Marrow
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9 Red Bone Marrow (stroma, hemopoietic cords, and sinusoidal capillaries)
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Blood Cell Lifelines 10 RBC: 7-8 days maturation in marrow. 120 days in circulation. Lymphocytes: 2-3 days maturation in marrow. Days to decades in circulation. Monocytes: 2-3 days maturation in marrow. Most 16 hours; some years in circulation.
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Blood Cell Lifelines Neutrophils: About 2 weeks maturation in marrow. 6-8 hours in circulation. Eosinophils: About 2 weeks maturation in marrow. 8-12 hours in circulation. Basophils: About 2 weeks maturation in marrow. 9-18 months in circulation. 11 Platelets: 5 days maturation in marrow. 10 days in circulation.
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Monophyletic theory of hemopoiesis All blood cells are derived from a common hemopoietic stem cell (HSC). HSC (Pluripotential stem cell - PPSC) - can also self renew - differentiates into other non-blood cells/ tissues / organs - have the ability to repair tissues after injury - expresses specific cell surface markers: CD34 + , CD90 + , CD38 -.
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  • Spring '16
  • Neil Warner
  • Bone marrow

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