ANTINEOPLASTIC-ANTINFLAMATORY.docx - Antineoplastic...

Antineoplastic
MOA -Affecting cell survival
-Boosting the immune system in its efforts to combat the abnormal cells
TYPES Alkylating Antimetabolites Antineoplastic
Antibiotics
Mitotic Inhibitors Hormones and
Hormone Modulators
Cancer Cell Specific
Agents
MOA React chemically
with portions of the
RNA, DNA, or
other cellular
proteins
Have chemical
structures like those
of natural metabolites
-Inhibit DNA
production in cells
that depend on
certain natural
metabolites to
produce their DNA
Not selective only
for bacterial cells;
toxic to human cells
-Break up DNA links
and others prevent
DNA synthesis
-Cytotoxic and
interfere w/cellular
DNA synthesis
Drugs that kill cells
as the process of
mitosis begins
-Inhibit DNA
synthesis
-Interfere w/ ability
of a cell to divide;
they block or alter
DNA synthesis, thus
causing cell death
Used in cancers that
are sensitive to
estrogen stimulation
-Some of them block
or interfere w/
estrogen receptors
sites to prevent growth
of the cancer and
cause cell death in
some situations
-used as antineoplastic
are receptor-site
specific or hormone
specific to block the
stimulation of growing
cancer cells that are
sensitive to the
presence of that
hormone
Treat chronic myeloid
leukemia (CML) and
CD117-positive
unresectable or
metastatic malignant
GI stromal tumors
(GIST)
-These drugs would not
have the devastating
effects on healthy cells
in the body and would
be more effective
against particular
cancer cells
- there are three
groups
1-protein tyrosine
kinase inhibitors
2-Epidermal growth
factor inhibitor
3- Proteasome inhibitor
INDICATIONS -Lymphomas,
leukemias,
myelomas, some
ovarian, testicular,
and breast cancers
and some
pancreatic cancers
-Tto of various
leukemias and some
GI and basal cell
cancers
-Squamous cell
carcinomas,
leukemias,
Adenocarcinoma
of the stomach and
pancreas
-Variety of tumors
and leukemias
- Breast Cancer
postmeno women or in
other women without
ovarian function
-Tto of Prostatic
cancer that are
sensitive to hormone
manipulation
-Leukemia
-Gastrointestinal
stromal tumor
CONTRA
INDIC
-Pregnancy and
Lactation
-Any know allergy
-Bone marrow
suppression
-Suppressed Renal
or Hepatic function
-Pregnancy and
lactation
-Individual w/ a
known allergy to any
of them
-Bone marrow
suppression, renal or
hepatic dysfunction
-Known GI
ulcerations or
ulcerative diseases
Pregnancy and
lactation
-Individual w/ a
known allergy to any
of them
-Bone marrow
suppression, renal
or hepatic
dysfunction
-Known GI
ulcerations or
ulcerative diseases
Pregnancy and
lactation
-Individual w/ a
known allergy to any
of them
-Bone marrow
suppression, renal
or hepatic
dysfunction
-Known GI
ulcerations or
ulcerative diseases
-Pregnancy and
lactation
Hypercalcemia
(Toremifene)
-Known allergy
- Renal or hepatic
dysfunction
-Pregnancy and
lactation
-Hepatic dysfunctio
-Pt w/ risk for
prolongated QT
intervals (hypokalemia,
Hypomagnesia or
taking drugs that
prolonging QT
- History of
Hypersensitivity.

Anti-inflammatory, Antiarthritis, and Related Agents
HISTAMINE? Salicylates (drugs that block