AntineoplasticMOA-Affecting cell survival -Boosting the immune system in its efforts to combat the abnormal cellsTYPESAlkylating AntimetabolitesAntineoplastic Antibiotics Mitotic InhibitorsHormones and Hormone ModulatorsCancer Cell Specific AgentsMOAReact chemically with portions of theRNA, DNA, or other cellular proteins Have chemical structures like those of natural metabolites-Inhibit DNA production in cells that depend on certain natural metabolites to produce their DNA Not selective only for bacterial cells; toxic to human cells-Break up DNA linksand others prevent DNA synthesis-Cytotoxic and interfere w/cellular DNA synthesis Drugs that kill cells as the process of mitosis begins -Inhibit DNA synthesis-Interfere w/ ability of a cell to divide; they block or alter DNA synthesis, thuscausing cell death Used in cancers that are sensitive to estrogen stimulation -Some of them block or interfere w/ estrogen receptors sites to prevent growthof the cancer and cause cell death in some situations-used as antineoplasticare receptor-site specific or hormone specific to block the stimulation of growing cancer cells that are sensitive to the presence of that hormoneTreat chronic myeloid leukemia (CML) and CD117-positive unresectable or metastatic malignant GI stromal tumors (GIST)-These drugs would nothave the devastating effects on healthy cells in the body and would be more effective against particular cancer cells - there are three groups1-protein tyrosine kinase inhibitors 2-Epidermal growth factor inhibitor 3- Proteasome inhibitorINDICATIONS -Lymphomas, leukemias, myelomas, some ovarian, testicular, and breast cancersand some pancreatic cancers-Tto of various leukemias and some GI and basal cell cancers-Squamous cell carcinomas, leukemias, Adenocarcinoma of the stomach and pancreas -Variety of tumors and leukemias- Breast Cancer postmeno women or inother women without ovarian function -Tto of Prostatic cancer that are sensitive to hormone manipulation -Leukemia-Gastrointestinal stromal tumorCONTRAINDIC-Pregnancy and Lactation-Any know allergy-Bone marrow suppression -Suppressed Renalor Hepatic function-Pregnancy and lactation-Individual w/ a known allergy to any of them -Bone marrow suppression, renal or hepatic dysfunction-Known GI ulcerations or ulcerative diseasesPregnancy and lactation-Individual w/ a known allergy to anyof them -Bone marrow suppression, renal or hepatic dysfunction-Known GI ulcerations or ulcerative diseasesPregnancy and lactation-Individual w/ a known allergy to anyof them -Bone marrow suppression, renal or hepatic dysfunction-Known GI ulcerations or ulcerative diseases-Pregnancy and lactationHypercalcemia (Toremifene)-Known allergy - Renal or hepatic dysfunction-Pregnancy and lactation-Hepatic dysfunctio-Pt w/ risk for prolongated QT intervals (hypokalemia,Hypomagnesia or taking drugs that prolonging QT- History of Hypersensitivity.
Anti-inflammatory, Antiarthritis, and Related AgentsHISTAMINE?Salicylates (drugs that block