quiz 4 - KimberlyNguyen December3,2009 BIO325...

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Kimberly Nguyen December 3, 2009 BIO 325 BIO 325 (Genetics): Quiz 4 1. Huntington’s Disease a. The name of the gene and the function of the gene product. i. Genetic disorder on chromosome 4 with mutation on HTT gene ii.  HTT provides instructions for making the “Huntingtin” protein iii. HTT involves a DNA segment, CAG. If there are 36-120 CAG repeats, the  person has Huntington’s disease.  b. Size of the gene and its location  i. The HTT gene is located on the short (p) arm of chromosome 4 at position  16.3. ii. located from base pair 3,046,205 to base pair 3,215,484, so about 169, 279  base pair long c. The number of exons and introns and the length of the coding region. i. 67 exons ii. 66 introns iii. 9432 base pairs for 3144 amino acids d. List the top 10 sequences for each protein with their known function. i. HD_Human: Huntingtin (organism: homo sapiens) Synthesis of the protein  Huntingtin, which helps expresses the gene disorder ii. B7XBM1_CALJA:Huntingtin (organism: Callithrix jacchus) Synthesis of the  protein Huntingtin, which helps expresses the gene disorder iii. HD_MOUSE: Huntingtin (organism: mus musculus) Synthesis of the protein  Huntingtin, which helps expresses the gene disorder iv. HD_RAT: Huntingtin (organism: rattus norvegicus) Synthesis of the protein  Huntingtin, which helps expresses the gene disorder v. Q9GM99_PIG: Huntingtin (organism: sus scrofa) Synthesis of the protein  Huntingtin, which helps expresses the gene disorder vi. B7U9A4_SHEEP: Huntingtin (organism: ovis aries) Synthesis of the protein  Huntingtin, which helps expresses the gene disorder vii. O42269_DANRE: Huntingtin (organism: Danio rerio) Synthesis of the protein  Huntingtin, which helps expresses the gene disorder viii. HD_TAKRU: Huntingtin (organism: danio rerio) Synthesis of the protein  Huntingtin, which helps expresses the gene disorder
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ix. Q4S7T9_TETNG: Huntingtin (tetraodon nigroviridis) x. P42859-2: chromosome 18 SCAF14712 (organism: tetraodon nigroviridis )  alternative combinations to form molecules with different functions e. Considering that a mutation in the gene results in the disease, how would you treat  this disease using gene therapy?   i. Huntington disease raises many eyebrows and has unanswered questions.  So, I would first start out with a culture of the cells that causes Huntington  disease. According to research one main gene besides HTT gene that has a  major effect on Huntington’s is the RCAN1 gene. By increasing levels of  RCAN1 will prevent cells from being affected by Huntington’s. So from here, I  will be manipulating this gene by adding different compounds to the gene, 
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This note was uploaded on 01/19/2010 for the course BIO Genetics taught by Professor Saxena during the Fall '08 term at University of Texas.

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quiz 4 - KimberlyNguyen December3,2009 BIO325...

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