Lectures 9 and 10 - Lectures 9 and 10 Gene Expression and...

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Lectures 9 and 10 Gene Expression and Protein Synthesis Plasma membrane receptor binding and signal transduction are the first steps in altering gene expression and subsequent protein levels in cells. The next steps we will discuss are: 1. Transcription factor activation 2. Transcription factor binding to DNA 3. RNA processing 4. mRNA translation into a protein Overview (Ref. 5)
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Transcription Factor Activation Transcription factors directly bind to DNA promoter regions to increase or decrease gene expression. The promoter region is the DNA region immediately preceding the transcription start site and regulates whether or not the RNA polymerase is able to start transcription. In general, transcription factors are proteins that exist in the cell in an inactive form. *The key concept here is they are already synthesized so their activity can be quickly controlled through posttranslation modifications (i.e. phosphorylation). Transcription factors (TFs) are found either in the cytoplasm
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This note was uploaded on 01/19/2010 for the course NTR 342 taught by Professor Tillman during the Fall '09 term at University of Texas at Austin.

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Lectures 9 and 10 - Lectures 9 and 10 Gene Expression and...

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