Lecture 15 - Lecture 15 Carbohydrate Metabolism Once...

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Lecture 15 Carbohydrate Metabolism Once glucose is taken into the cell, it has several options metabolically. Normally, points along the metabolic pathway where several options are available (branchpoint) or the reaction is irreversible is a regulatory location. Glucose will either be: 1. used for energy (ATP) production 2. stored as glycogen 3. stored as fat (fatty acids) 4. used to make amino acids or DNA/RNA
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Overview of Glucose Metabolism (Ref. 3)
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Carbohydrate Metabolism (Continued) Glycolysis
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Pyruvate Dehydrogenase Acetyl-CoA fate is oxidation or fatty acid synthesis. Pyruvate Carboxylase
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Glycolysis (cytoplasm) 1. Glucose Glucose-6-P Glucokinase liver mainly, low affinity (high K m ) Gluc-6-P has no affect Hexokinase all tissues, high affinity (low K m ) (-) Gluc-6-P Hexokinase/Glucokinase Activity
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Fruc-6-P Fruc-1,6-P Phosphofructokinase Phosphoenolpyruvate (PEP) Pyruvate Pyruvate Kinase Step after glycolysis Transporter carries pyruvate into mitochondria
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This note was uploaded on 01/19/2010 for the course NTR 342 taught by Professor Tillman during the Fall '09 term at University of Texas at Austin.

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Lecture 15 - Lecture 15 Carbohydrate Metabolism Once...

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