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Lecture+7+Neuropsych+Epi - Neuropsychological Methods and...

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1 Neuropsychological Methods and Concepts Basic concept: Linking behavior to underlying neural mechanisms Methods include studies of normal individuals and those with brain lesions - stroke and tumor Correlation of lesions with lost function More recently, cognitive neuroscience has applied imaging and cognitive methods to define how the brain performs cognitive tasks Stroke - Typical Model of Focal Brain Lesion Gradual or sudden vessel occlusion results in inadequate blood supply and death of tisssue (infarction) New stroke - brain swelling
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2 Visualization of Stroke Postmortem MRI Cognitive Testing Development of cognitive tests that tap specific functions Tests often validated by administration to patients with focal brain lesions Tests developed to define both a cognitive ability and an anatomical localization Examples: Tests of frontal/executive functioning, memory, language, visuospatial ability
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3 Language Areas of Brain Strokes in Broca’s and Wernicke’s areas helped to explain how language function was localized in the brain, leading to the modern study of aphasia (loss of language) Lesions in Broca’s and Wernicke’s Aphasia Broca
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