Lecture+9+Anatomic+changes+aging - 1 Neuroanatomy of Aging...

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Unformatted text preview: 1 Neuroanatomy of Aging Questions: What brain structures change size with age (gross anatomy)? What do regionally specific changes in age tell us about mechanisms of aging, cognitive function, and what is “normal” What are the microscopic anatomical changes underlying gross anatomical change Neuroanatomical Changes in Aging: Methodological Issues Is disease part of normal aging? Should we exclude people with Alzheimer’s disease or dementia from our studies Longitudinal or cross sectional studies? What is the best method? Imaging Post-mortem (rules out longitudinal studies!) 2 Cerebral Atrophy Normal Brain Atrophy Cross Sectional Autopsy Study: Age vs Brain Volume 47 men, 44 women, brains removed at autopsy Diseased subjects excluded Left and Right Hemisphere volumes measured separately Corrected for secular effects: cohort effect - people born at later times develop larger brains men women Volume Loss = .2%/year 3 Example - Brain Volume with MRI MRI scans on 370 people aged 18-97 (cross sectional) Repeated scans on 79, 1.8 years later (longitudinal) Older subjects divided into normal, and those with Alzheimer’s disease (AD) MRI segmented to measure brain volume (normalized to head size) MRI Segmentation “Raw” MR Image: note grey, white, spinal fluid, scalp MRI Segmented: note grey, white, spinal fluid Further segmentation: all tissue types cortical grey, subcortical grey, ventricular CSF, cortical CSF, Grey + White = Whole Brain Volume 4 65 70 75 80 85 90 10 20 30 40 50 60 70 80 90 100 Age (Years) Brain VOlume (%) Fotenos et al., Neurology , 2005 WHOLE-BRAIN ATROPHY Cross sectional: Age vs Volume Nondemented Alzheimer’s Longitudinal Whole Brain Atrophy Fotenos et al., Neurology , 2005 60 65 70 75 80 85 60 65 70 75 80 85 90 95 100 nWBV (%) Age (Years)...
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This note was uploaded on 01/20/2010 for the course NEUROSCIEN Neuroscien taught by Professor Jagust during the Fall '09 term at École Normale Supérieure.

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Lecture+9+Anatomic+changes+aging - 1 Neuroanatomy of Aging...

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