Lecture+16+Stroke - What is Stroke? Disease of the...

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon
1 What is Stroke? Disease of the cerebrovascular system with abnormalities in blood supply leading to tissue death Usually caused by occlusion of a blood vessel Leads to ischemia infarction necrosis Can be caused by bleeding in the brain (intracerebral hemorrhage) Types of Stroke Thrombotic slow occlusion of a vessel supplying the brain intracerebral (ie, middle cerebral artery) or extracranial (ie, carotid artery) Embolic Blood clot fragments from a larger thrombus to brain May be cardiogenic (arising from the heart) Hemorrhagic Bleeding in the brain
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 Stroke Symptoms Generally sudden onset Can sometimes evolve over hours Neurological symptoms Weakness or paralysis of one side of the body Loss of sensation - touch, vision Cognitive changes - aphasia Symptoms related to location Outcome related to size of lesion and general health Many strokes are asymptomatic Transient Ischemic Attack (TIA) Short duration stroke-like symptoms Defined as lasting < 24 hours, usually lasts minutes Associated with increased subsequent stroke risk A “warning stroke” with almost the same significance as a stroke itself as far as associations with other vascular mortality and morbidity
Background image of page 2
3
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
4 Hemorrhage Occlusion of Carotid by clot (thrombus) Clot travels from heart to brain (embolus)
Background image of page 4
5 Thomas Willis (1621-1675): Physician, anatomist, psychologist MR Angiography Carotid Artery in Neck Circle of Willis
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
6 Acute stroke, accompanied by brain swelling (edema)
Background image of page 6
7 Chronic (longstanding) stroke is an area of tissue loss T1 T2 Infarct proximal middle cerebral artery Infarct, Superior temporal gyrus Acute
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
8 MRI PET Glucose Metabolism Chronic Infarct MR of Stroke Acute Swelling T2 signal change Chronic Loss of tissue
Background image of page 8
9 Lacunar stroke: Small subcortical infarction caused by occlusion of small penetrating arteries. Common in hypertension and diabetes
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 10
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 01/20/2010 for the course NEUROSCIEN Neuroscien taught by Professor Jagust during the Fall '09 term at École Normale Supérieure.

Page1 / 21

Lecture+16+Stroke - What is Stroke? Disease of the...

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online