Review+Session - Major Themes Aging is related to...

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1 Major Themes Aging is related to development Increased variability with age Selective vulnerability of brain regions Compensatory response to aging Interactions between vascular system and brain Protein alterations in neurodegeneration Synapses are important Genes tell (only) part of the story The Aging Brain: Aging and Development are Linked Time Early life: Development Mid life: Stability Late life: Decline “Cognitive Ability” Functional Dependence Functional Independence
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2 Aging is Associated with Increased Variability Cognition declines with age but variability is considerable Brain shows atrophy with age, but variability increases Variability is related to regional vulnerability and disease There is great individual variation in age vs performance These are longitudinal data on rates of change for individual subjects
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3 Regional Vulnerability: Different effects for age vs disease Frontal cortex is especially subject to atrophy Dopaminergic neuronal decline with age Cholinergic loss in Alzheimer’s disease Hippocampal volume loss in Alzheimer’s disease Vulnerability of systems is related to behavioral manifestations of age Dorsolateral Prefrontal Orbital Frontal Primary Visual Superior Parietal Somatosensory Age Effects are Strongest in the Frontal Lobes Hippocampus 0.5%/year 0.2%/year 0.4%/year
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4 Neuron Loss shows regional variability: Neurons are lost in the substantia nigra with age at a rate of 5-8%/decade This results in changes in the brain dopamine system with age MRIs: Hippocampal Atrophy in AD Alzheimer’s Disease Normal Mild Atrophy
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Review+Session - Major Themes Aging is related to...

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