BB lecture 11-20-09 gene regulation - continued

BB lecture 11-20-09 gene regulation - continued - Stages in...

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Stages in gene expression that can be regulated in eukaryotic cells 1. Chromatin modification 1. Transcription (most common reg. point) 3. RNA processing 4. RNA degradation 5. Translation 6. Protein modification 7. Protein degradation
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Chapter 18 (p.366-373) Gene regulation (continued) Learning objectives: Explain what cytoplasmic determinants are and their effect on cell differentialtion Distinguish between developmental determination and differentiation Give two sources of signals for cell differentiation Explain the role of master regulatory genes in development Understand the morphogen gradient hypothesis proposed for Drosophila development terms to know include…morphogenesis, cytoplasmic determinants, cell induction, positional information, homeotic genes, bicoid gene/protein, myoD gene. .
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Revisit: Epigenetic Inheritance The inheritance of traits transmitted by mechanisms not directly involving the nucleotide sequence is called epigenetic inheritance
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differential gene expression results in different cell types starting with a fertilized egg,… - gene expression is synchronized for the development of cells, tissues, organs, organ systems, and the whole organism The Genetic Program for Embryonic Development: the transformation from zygote to adult results from - cell division , - cell differentiation , and - morphogenesis
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Sequence of cell development = sequence of gene expression: Cell Determination - cell is commited Cell Differentiation - c ell begins producing tissue-specific proteins .. Morphogenesis - cell develops specialized structure/function
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There are two sources of signals for cell differentiation cytoplasmic determinants induction
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BB lecture 11-20-09 gene regulation - continued - Stages in...

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