BB lecture 11-30-09 cell cycle, mitosis

BB lecture 11-30-09 cell cycle, mitosis - Chapter 12...

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Chapter 12 (pp.228-243) Nuclear division (mitosis) and the cell cycle Learning objectives: Know the phases of the cell cycle Know the phases of mitosis and how/where chromosomes move Compare cytokinesis in animal and plant cells Describe the roles of Contrast the mitosis of dinoflagellates and diatoms with that of animal cells Describe the division of prokaryotes by binary fission terms to know include: centrosome, centriole, centromere, chromatid, cleavage furrow, chromosomal mutation by deletion, inversion, duplication, translocation…
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The cell cycle of “typical” human cell: 1 division/24 hours INTERPHASE G 1 S (DNA synthesis) G 2 Cytokinesis Mitosis MITOTIC (M) PHASE [10-12 hours] [< 1 hour] [5-6 hours] [4-6 hours] Figure 12.5
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Telomere/centromere. .from the Greek words telos meaning “ end ”, or centros meaning central ”, and meros meaning “ par t” ... [Compare to Figure 12.4 in text]
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Figure 12.6
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Fig. 12-9 Cleavage furrow 100 µm Contractile ring of microfilaments Daughter cells (a) Cleavage of an animal cell (SEM) (b) Cell plate formation in a plant cell (TEM) Vesicles forming cell plate Wall of parent cell Cell plate Daughter cells New cell wall 1 µm Cytokinesis: animal cells vs plant cells
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The Mitotic Spindle: formation detail The mitotic spindle is made of microtubules that control movements of chromosomes Assembly of spindle microtubules begins in the centrosome , the microtubule organizing center ( MOC ) The centrosome replicates , forming two centrosomes that migrate to opposite ends of the cell, as spindle microtubules grow out from them An aster (a radial array of short microtubules) extends from each centrosome The spindle = the centrosomes + the spindle microtubules + the asters Some spindle microtubules attach to the kinetochores of chromosomes and move the chromosomes to a mid-cell position – these are called kinetochore microtubules In anaphase, sister chromatids separate and move along the kinetochore microtubules toward opposite ends of the cell The microtubules shorten by depolymerizing at their kinetochore ends Nonkinetochore microtubules from opposite poles overlap and push against each other, elongating the cell
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BB lecture 11-30-09 cell cycle, mitosis - Chapter 12...

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