RevisedOutline13 - Outline 13 (Section not covered on Tests...

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Outline 13 (Section not covered on Tests is in Gray) Drugs & Addiction: PART 2: Neural Plasticity and Addiction "...addiction represents the pathological usurption of neural processes that normally serve reward-related learning" I. Many addictive drugs enhance activity of the mesolimbic dopamine system Nucleus accumbens is thought to be involved in learning reinforcement. Prefrontal cortex is thought to be important for "goal directed" behavior, impulse control, decision making ("executive function"), working memory, value assignment to rewards. II. Relapse and Incentive-Sensitization Relapse is considered to be a hallmark of addiction. It often occurs with exposure to stimuli previously associated with the drug. This includes external (e.g., locations, paraphenalia) and internal (feelings, small amounts of the drug) stimuli. Sensitization of "positive-incentive value" of drug-related stimuli: With repeated use, the drug-related stimuli become enhanced in their ability to elicit
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RevisedOutline13 - Outline 13 (Section not covered on Tests...

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