Lecture2_building blocks

Lecture2_building blocks - Building Blocks DNA RNA and...

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Building Blocks: DNA, RNA and Proteins are polymers • Double helix • Building Blocks • Base pairing • Single-strand nucleic acid - RNA • DNA flexibility, lability • Protein overview, structure and function DNA - A double helix Structure stabilized in several ways: • large number of H-bonds between base pairs in center of structure • hydrophobic (hydrophobic effect) & van der Waals interactions b/t stacked base pairs further stabilizes double helix • charged phosphate groups are hydrophilic and interact with aqueous environment • The above provide stability, but double helix is flexible about long axis
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RNA and DNA • Nucleic acids are polymers of nucleotides • Nucleotides have many additional roles in biochemistry GTP - participates in intracellular signaling and is an energy reservoir ATP - energy carrier Bases of nucleotides
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Base structures found in DNA DNA vs. RNA
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Names of bases, nucleosides and nucleotides
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Subunits form polymers via condensation reactions • Phosphodiester bond formed by condensation reaction • 3’ carbon forms an ester bond with phosphate group
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Sequence of monomers in the polymer is written left to right, 5’ to 3’ CAG.
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