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Lecture6_Prok gene reg

Lecture6_Prok gene reg - Gene Regulation in Prokaryotes...

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Gene Regulation in Prokaryotes •Regulation basics in bacteria • promoters and proteins • RNA Polymerase, aka “RNA Pol” & “RNAP” • sigma factors • operon organization & regulation • activated vs repressed • examples: ! trp operon ! lac operon ! lux operon
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operon organization & regulation - some examples Two general kinds of operons: • repressible – txn* usually on but can be inhibited when a specific small molecule binds to a regulatory protein ( ex. trp operon) • inducible – txn* usually off but can be stimulated when specific small molecule interacts with a regulatory protein (ex. lac or lux operon ) * Note: txn = transcription
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1 promoter = 1 mRNA = several genes = several proteins Recall: • Prokaryotic genomes have operon structure - functional clustering of genes • Operon - entire stretch of DNA needed for enzyme production for this pathway (operator, promoter, genes they control) • Allows for coordinate regulation Operon Promoter Operator Genes RNA polymerase Polypeptides A B C C B A
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