ch369_f09_class5_notes

Ch369_f09_class5_not - T.A.sCassidy& ,Sept14 Cassidy11amtonoon.3.422FMBB Ken3pm,cubicleA,1stfloor Welch Yes forexam1withoutl

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office hour this week on Monday, Sept 14.        Cassidy - 11 am to noon. 3.422F MBB.        Ken -  3 pm, cubicle A, 1st floor  Welch.            No calculators allowed on exam 1.   
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Do you need to know amino acids for exam 1?     Yes.    You should be able to do the study questions  for exam 1 without looking at book or notes.
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(examples of protein structure and  function) Animals need a constant supply of oxygen. Myoglobin and hemoglobin are oxygen binding  proteins. Myoglobin is abundant inside muscle cells. Hemoglobin is found in red blood cells, and  transports O 2 . “Proteins” (continuing chapter 4 of textbook)
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prosthetic group ” called a “ heme ”. The heme group is bound in a hydrophobic pocket in the  protein core. The heme group can reversibly bind oxygen  O 2 . Myoglobin ribbon  diagram  (wikipedia). heme Myoglobin was the  first protein to  have its structure  determined (1958).   Kendrew received  Nobel prize in  1962.
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The iron (Fe 2+ ) gives the heme a red color. Fe 2+  can bind 6 ligands (“octohedral coordination”). 4 ligands contributed by the porphoryrin ring, one ligand  from a histidine, one space available for binding O 2 . O 2 heme
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Fraction of  myoglobin  molecules with O 2   bound. This binding  curve has a  “hyperbolic”  shape. O 2  pressure (torr) The binding curve says:  When there is a lot of O 2   present, a large fraction of myoglobin molecules have  O 2  bound. Myoglobin binding  O 2
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structure determined, it is one of the most well  studied proteins in biology. Although it is clear that myoglobin does bind O 2 , its  physiological function is still not fully understood.  Oxygen storage in muscle tissue, and/or perhaps binding  nitric oxide (NO) or binding oxygen free radicals  (O 2 - )? Surprisingly, mice that have been genetically 
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This note was uploaded on 01/21/2010 for the course CH 369 taught by Professor Kbrowning during the Fall '07 term at University of Texas at Austin.

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Ch369_f09_class5_not - T.A.sCassidy& ,Sept14 Cassidy11amtonoon.3.422FMBB Ken3pm,cubicleA,1stfloor Welch Yes forexam1withoutl

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