ch369_f09_glycol_notes

Ch369_f09_glycol_not - Chapter 10 Glucose metabolism Todays topic is glycolysis What is glycolysis The metabolic pathway that converts glucose to

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Chapter 10 - “Glucose metabolism” What is glycolysis? The metabolic pathway that converts glucose to pyruvate. Today’s topic is “ glycolysis ”. Overall reaction of glycolysis:
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Glycolysis starts with a molecule with high energy content (glucose) and converts it to a molecule with lower energy content (pyruvate). Converts ADP to ATP. High energy content lower energy content
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Glycolysis is an oxidation-reduction reaction: Glucose gets oxidized to pyruvate. NAD+ gets reduced to NADH.
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NAD + A cofactor to remember.
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Why study glycolysis? Almost all cells and almost all living things use glycolysis to make ATP. It’s the first complex metabolic pathway to be well understood.
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Glycolysis is an enzyme-catalyzed reaction. Actually, the reaction is catalyzed in 10 steps by a series of enzymes. (sorry, not my fault!) Where does glycolysis happen? In the cytosol !
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Where does glycolysis happen? In the cytosol ! cytosol Diagram of a prokaryotic cell
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Where does glycolysis happen? In the cytosol ! cytosol Diagram of a eukaryotic cell
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10 steps in glycolysis. Each step is catalyzed by its own enzyme. Will make a few comments on each step. Also, should mention that glycolysis is regulated. Why regulated? Why so many steps? glucose 2 pyruvate
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Step 1: glucose converted to glucose-6-phosphate by hexokinase. Uses ATP. What’s with that, I thought we were supposed to make ATP?
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The first 5 steps in glycolysis are sometimes called “preparatory phase” or “energy investment phase”. Our text uses “ energy investment phase ”. Last 5 steps in glycolysis are called “generation phase” or
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This note was uploaded on 01/21/2010 for the course CH 369 taught by Professor Kbrowning during the Fall '07 term at University of Texas at Austin.

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Ch369_f09_glycol_not - Chapter 10 Glucose metabolism Todays topic is glycolysis What is glycolysis The metabolic pathway that converts glucose to

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