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handout2_blank - Structural Biochemistry TA Phu Tran...

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Structural Biochemistry Dr. Lukas Buehler TA Phu Tran pdtran@ucsd.edu Sections A03 W 1 - 3 pm Solis 111 OH after class by appointment Handout 2 Amino Acids in Solution The human physiological pH is near 7.4. Amino acid, having both a negative end (carboxyl terminal) and a positive end (amino terminal), will change its depending on the pH of the solution it is in. In basic conditions (high pH), the zwitterion form is deprotonated (high [OH - ] pulls [H + ] from the amino acid) at the _ ________ _ terminal. In acidic conditions (low pH), the zwitterion form is protonated (high [H + ] adds [H + ] to the amino acid) at the _ ________ _ terminal. At pI (the isoelectric point), all amino acids in the solution are zwitterions and the net charge of the molecule is _ ________ _. At pK 1 (the pK of the carboxyl end), there are equal amounts of zwitterions and _ ________/________ _ form. At pK 2 (the pK of the amino end), there are equal amounts of zwitterions and _ ________/________ _ form. Number of protons dissociated from amino acid Certain amino acids have ionizable side chains (such as Glu, Asp, and Tyr). These side chains have a pK R where half the concentration of amino acids would have the side chain protonated and half would be deprotonated. The amino acids with a net positive charge on the side chain at physiological pH are _ ________ _, _ ________ _, and _ ________ _. The amino acids with a net negative charge on the side chain at physiological pH are _ ________ _ and _ ________ _. The Henderson-Hasselbalch equation describes the relationship between pH, pK, and concentration of an acid/base and its conjugate
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This note was uploaded on 01/23/2010 for the course BIBC 100 taught by Professor Nehring during the Summer '07 term at UCSD.

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handout2_blank - Structural Biochemistry TA Phu Tran...

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