Lecture 08

Lecture 08 - Lecture 8 Oxidative Phosphorylation (II) 0...

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0 Lecture 8 Oxidative Phosphorylation (II)
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1 Electron Transport Chain
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2 e-
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3 Transfer of electrons from CoQ to Complex III Pumping of 4 H + through the ―Q cycle‖ Transfer of electrons from CoQ (soluble in lipid) Through Iron-Sulfur Protein to cytochrome c 1
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4 From Complex III to Complex IV Electrons to soluble cytochrome c Apoptosis (programmed cell death) — cytochrome c released out of mitochondrion to cytosol
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5 Complex IV: Cytochrome c Oxidase Cytochromes Reduction of O 2 to H 2 O Pumps 2 H + Also uses up 2 H + in reduction of O 2 to add to gradient
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6 Cytochrome c Oxidase dimer 13 subunits — cytochrome a , a 3 , Cu A , Cu B Reduction of O 2 — cytochrome a 3 -Cu B complex
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7 Cytochrome Oxidase mechanism
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8 Cytochrome Oxidase mechanism
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9 A pair of electrons: Pumps 4 H + by Complex I Pumps 4 H + by Complex III Pumps 2 H + by Complex IV
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10 Reduction of O 2 in oxidative phosphorylation — Is there a downside? If only partially reduced, create reactive oxygen species (ROS) Superoxide radical Or worse hydroxyperoxyl radical HO 2 Most potent ROS is hydroxyl radical Superoxide + Hydrogen Peroxide
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11 Free Radicals Extract e - from other molecules — create other free radicals and thereby initiate chain reaction Oxidation of polyunsaturated lipids Damage to DNA Mitochondrion is probably most susceptible
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Lecture 08 - Lecture 8 Oxidative Phosphorylation (II) 0...

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