Lecture 07

Lecture 07 - Lecture 7 Oxidative phosphorylation (I) 0...

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0 Lecture 7 Oxidative phosphorylation (I)
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1 Electron Transport: Harnessing electrons from NADH and FADH 2 10 NADH ~ 25 ATP 1. Glyceraldehyde-3- phosphate dehydrogenase 2. Pyruvate dehydrogenase 3. Isocitrate dehydrogenase 4. a- ketoglutarate dehydrogenase 5. Malate dehydrogenase 2 FADH 2 ~ 3 ATP 1. Succinate dehydrogenase
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2 Electron Transport: Harnessing electrons from NADH and FADH 2 e - flow „downhill‟ To O 2 Reduce O 2 to H 2 O And at the same time create an ion gradient across the membrane by pumping H + The ion gradient drives ATP synthesis
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3 Mitochondrion Ellipsoidal, depending on cell Origins from bacterial symbiosis? Contains DNA (and RNA and ribosomes) Two compartments Enzymes of electron transport in inner membrane Increase in inner membrane through infoldings — cristae Ion gradient generated across inner membrane through electron transport
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4 Inner Membrane Outer Membrane Cytosol H + Cytosol Mitochondrion Cristae Matrix Intermembrane space Outer membrane: permeable to most small molecules Inner membrane: impermeable to …
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5 Terry Frey, SDSU
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6
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7 How do electrons get from NADH to O 2 ? Specific sequence of electron transfers — follows reduction potential increase Reduction (redox or oxidation- reduction) potential? Black Box
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8 How do we know which way to go? Redox Reactions Electrons passed from electron donor ( reductant/reducing agent ) to electron acceptor ( oxidant/oxidizing agent ) 1/2 O 2 + NADH + H + H 2 O + NAD + Half-reactions NADH NAD + + H + + 2 e - electron donor 1/2 O 2 + 2 H + + 2 e - H 2 O electron acceptor
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This note was uploaded on 01/23/2010 for the course CHEM 674121 taught by Professor Wang,wei during the Winter '10 term at UCSD.

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Lecture 07 - Lecture 7 Oxidative phosphorylation (I) 0...

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