Lecture 04

Lecture 04 - Lecture 4 Gluconeogenesis 1 Blood glucose...

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1 Lecture 4 Gluconeogenesis
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2 Lehninger, Fig. 23-11 Blood glucose level is critical
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3 Compartments Citric Acid Cycle — mitochondrion Gluconeogenesis cytoplasm
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4 Gluconeogenesis Covert pyruvate to glucose Mostly in liver, some in kidney Non-carbohydrate precursors Lactate Most amino acids, except Leu and Lys Glycerol ! Not fatty acids in animals In animal, no conversion from Acetyl-CoA to oxaloacetate Cori Cycle
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5 Lactate converted to pyruvate
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6 Glycerol converted to DHAP
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7 GAPDH PG kinase PG mutase Enolase Pyruvate Kinase Hexokinase PFK Aldolase TIM Glycolysis: How do you go backwards? Principle: Breakdown and synthesis have key steps that are different
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8 Reactions of glycolysis Note difference between ’ and G Why the difference?
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9 G Negative — Spontaneous reaction How does ratio of Products/Reactants affect reaction? ln( ) 100 + 4.61 10 + 2.3 1 0 0.1 - 2.3 0.01 - 4.6 More Reactants than Products More Products than Reactants A ‘feeling’ for concentrations
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10 Concentrations of metabolites
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11 Pyruvate set to 0 -22
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12 Pyruvate to Oxaloacetate
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Lecture 04 - Lecture 4 Gluconeogenesis 1 Blood glucose...

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