Lecture 03

Lecture 03 - 1 Lecture 3 Glycolysis(II 2 Summary of 10...

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Unformatted text preview: 1 Lecture 3 Glycolysis (II) 2 Summary of 10 steps of glycolysis Glucose + 2P i + 2ADP + 2NAD + -> 2pyruvate + 2ATP + 2NADH + 2H + + 2H 2 O 3 Summary of 10 steps of glycolysis 4 Summary of 10 steps of glycolysis 5 Summary of 10 steps of glycolysis GAPDH PG kinase PG mutase Enolase Pyruvate Kinase Hexokinase PGI PFK Aldolase TIM 6 Glycolysis Glucose Now what? 7 What happens to pyruvate? When there’s no oxygen around? • Muscle under exertion Note: Glycolysis generated ATP — will be used in lots of reactions by the cell to regenerate ADP NADH — Mainly used in oxidative phosphorylation (need O 2 ) to regenerate NAD + 8 Fate of pyruvate Yeast & microorganisms (anaerobic) Muscle & microorganisms (anaerobic) Complete oxidation (aerobic) 9 NAD + is regenerated from the metabolism of pyruvate 10 Alcoholic Fermentation (anaerobic) Pyruvate decarboxylase is not present in animals Glucose + 2P i + 2ADP + 2H + --> 2ethanol + 2CO 2 + 2ATP + 2H 2 O Glucose + 2P i + 2ADP + 2NAD + -> 2pyruvate + 2ATP + 2NADH + 2H + + 2H 2 O v.s. 11...
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This note was uploaded on 01/23/2010 for the course CHEM 674121 taught by Professor Wang,wei during the Winter '10 term at UCSD.

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Lecture 03 - 1 Lecture 3 Glycolysis(II 2 Summary of 10...

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