Chem 30A, W’06 Prof. Garrell CHEM 30A Week 7/8 Synopsis: Substitution & Elimination Reactions: the Beginning Goals and Assignments for Feb. 24 through Mar. 3 TOPICS: • General substitution (S N 1 and S N 2) reactions • Common nucleophiles and the products they form • Solvent properties: polarity; dielectric constant; protic/aprotic • S N 1 and S N 2 reaction mechanisms, kinetics and energetics • Factors determining reactivity patterns GOALS: • Be able to recognize Brønsted and Lewis acids and bases in the context of nucleophilic substitution and β-elimination reactions, and to describe these reactions with chemical equations and curved arrow notation; • Develop a knowledge base of different solvents and their properties; • Be able to recognize common nucleophiles and leaving groups, and understand the structural origins of their reactivities; • Understand how solvents influence reactivities of nucleophiles; • Understand the stereochemistry of S N 1 and S N 2 reactions;
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