tlc - instructor Warning You will be using a low power UV...

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ORGANIC CHEMISTRY LANEY COLLEGE CHEM 12A Thin Layer Chromatography (TLC) Analysis of Analgesic Drugs Reading Experiment 10 in Pavia (pp 73-78). Read all of the required reading at the beginning of the experiment, especially the on Analgesics (p.61) and Identification of Drugs (p. 72). Prelab Include the usual introductory parts plus find and draw in your notebook the structure of all of the analgesics that you will examine during the experiement (see below). Procedure Follow the procedure in the experiment except for the following items: a. although the instructor will demonstate how to make a micropipet, you may use ones that are provided b. only prepare one reference plate, not two. c. the analgesics that you will examine are: acetaminophen, aspirin, caffeine, ibuprofen, and salicylamide These are the standards that should appear on your reference plate and which will be in the reference mixture. Perform analysis on two known over-the-counter analgesic tablets plus at least one unknown tablet (see your
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Unformatted text preview: instructor). Warning: You will be using a low power UV lamp that can cause damage to your eyes if you stare directly into the lamp. So don't stare into the lamp! To complete the experiment Put all measured R f values in a Table. Sketch all TLC plates directly in your notebook, as accurately as possible. (you should be able to measure R f values from your pictures in the notebook, if needed). Be sure to report the R f of all observed components in the unknowns that you examine. Identify any components of the known and unknown analgesic tablets by comparing R f values to known analgesics (from the reference plate). Answer Questions 1-6 on p. 78 (Optional exercise: perform an Internet search on any of the analgesics listed above and include in your conclusion a very brief history of it.) Version 2.2, 3/1/07...
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