Topic 2 Talaro7th-Chapter 9

Topic 2 Talaro7th-Chapter 9 - Chapter 9(Talaro Genetics I...

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Chapter 9 (Talaro) - Genetics I. Nature of genetic material A. Genome = total genetic material of a cell or virus 1. double-stranded DNA in cells 2. DNA or RNA in viruses B. Flow of genetic information [Fig. 9.8] 1. Storage of genetic information & transmission to offspring. 2. Expression of genetic information within the cell to maintain cell's life - Genotype and phenotype – significance of being haploid vs diploid - Structural genes encode functional products (e.g., proteins, rRNA, tRNA) C. Composition: Nucleotide = nucleic acid base + ribose + phosphate (also Chap 2, Fig. 2.23 – 2.26) D. DNA structure [Fig. 9.4] 1. Nucleotides joined via covalent (phosphodiester) bonds to form 1 strand - Polynucleotides have polarity [3' -> 5' polarity vs 5' -> 3' polarity] 2. Double helix model: 2 antiparallel nucleotide strands (A:T / G:C) are held together by hydrogen bonds II. DNA replication A. Semiconservative [Fig. 9.5] 1. Origin of replication 2. Bidirectional replication 3. Replication fork
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Topic 2 Talaro7th-Chapter 9 - Chapter 9(Talaro Genetics I...

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