Topic 6 WeeksChp2[5th] - IV. Unique features of HIV...

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Chapter 2 [Weeks, Alcamo] – Viruses and HIV I. Cell & Molecular Biology A. Proteins = polymers of amino acids [Figs. 2.1, 2.2, 2.3] B. Nucleic acids = DNA & RNA [Figs. 2.4] 1. Nucleotides – deoxyribose and ribose 2. Purines & pyrimidines C. DNA copied into RNA by RNA polymerase = transcription [Fig. 2.5] D. DNA replication by DNA polymerase [Fig. 2.6] II. Structure of viruses A. Viral size [Fig. 2.8 B. Viral ‘shape’ [Fig. 2.9] C. Viral structural components [Figs 2.10, 2.11] 1. Naked virus 2. Enveloped virus III. Overview of general viral replication steps [Fig. 2.13] A. Adsorption – viral surface proteins interact with cell surface receptor (s) B. Penetration (entry) – viral genetic material carried into cell C. Uncoating – release of viral genome into cell D. Synthesis of viral nucleic acid and viral proteins E. Assembly – new viruses (virions) are put together using accumulated nucleic acid genomes and viral ‘structural’ proteins F. Release – virions get out of cell through either cell lysis or budding [Fig. 2.15]
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Unformatted text preview: IV. Unique features of HIV replication A. Role of CD4 and chemokine receptors in adsorption/attachment [Fig. 2.12; Box 2.3] 1. Membrane fusion between cell membrane and viral envelope B. HIV replication cycle retroviruses use reverse transcription , copying their RNA genome into a double-stranded DNA molecule [Figs. 2.14, 2.7] 1. Productive (lytic) infection 2. Latent (lysogenic) infection C. Transport of HIV DNA into nucleus and integration into host cell chromosome ( provirus ) 1. Role of viral integrase D. Expression of viral genes encoded in provirus uses host cells RNA polymerase. E. Assembly 1. Role of viral protease V. HIV genome [Provirus sequence depicted in Fig. 2.17] A. Structural genes: gag , pol , env B. Regulatory genes: tat , rev (as examples) VI. HIV genetic relatedness [Fig. 2.18] A. HIV-1 1. Group M (subgroups/clades) 2. Group N 3. Group O B. HIV-2 VII. Review Questions (1, 2, 4 9, 11, 13 15)...
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Topic 6 WeeksChp2[5th] - IV. Unique features of HIV...

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