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Unformatted text preview: IV. Unique features of HIV replication A. Role of CD4 and chemokine receptors in adsorption/attachment [Fig. 2.12; Box 2.3] 1. Membrane fusion between cell membrane and viral envelope B. HIV replication cycle retroviruses use reverse transcription , copying their RNA genome into a double-stranded DNA molecule [Figs. 2.14, 2.7] 1. Productive (lytic) infection 2. Latent (lysogenic) infection C. Transport of HIV DNA into nucleus and integration into host cell chromosome ( provirus ) 1. Role of viral integrase D. Expression of viral genes encoded in provirus uses host cells RNA polymerase. E. Assembly 1. Role of viral protease V. HIV genome [Provirus sequence depicted in Fig. 2.17] A. Structural genes: gag , pol , env B. Regulatory genes: tat , rev (as examples) VI. HIV genetic relatedness [Fig. 2.18] A. HIV-1 1. Group M (subgroups/clades) 2. Group N 3. Group O B. HIV-2 VII. Review Questions (1, 2, 4 9, 11, 13 15)...
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