Topic 10 Talaro7th-Chapter 13

Topic 10 Talaro7th-Chapter 13 - Chapter 13 Microbe-Human...

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Chapter 13 – Microbe-Human Interactions I. Overview A. Microbial interactions with humans 1. Normal (resident) microflora: mutualism, commensalism 2. Pathogen: parasitism Infection vs. Disease B. Associations between microbes and humans [Fig. 13.1] 1. Contact / exposure 2. Invasion 3. Infection 4. Disease (course of disease; Fig. 13.13) II. Normal resident microflora found on skin and mucous membrane-lined internal systems; not found in internal tissues, organs or body fluids – Revisit/review this material on your own; I have already discussed these microbes as part of nonspecific host defenses. [Figs. 13.2 – 13.6, Tables 13.1, 13.2] A. Roles of resident microflora 1. Modify the environment; e.g. acid production 2. Microbial antagonism; occupy space, produce antimicrobial chemicals B. “Manipulating” microflora 1. Probiotics (Insight 12.3, pg. 365) 2. ‘Germ-free’ animals [Insight 13.1] C. Viruses as “normal” microflora 1. ~10% of human genome has been identified as endogenous retroviral sequences III. From exposure to disease: portal of entry – adhesion – invasion – multiplication – infection of target tissue – disease – portal of exit
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Topic 10 Talaro7th-Chapter 13 - Chapter 13 Microbe-Human...

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