Topic 12 WeeksChp3[5th] - a. Incorrectly refers to CD8 + T...

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Chapter 3 [Weeks, Alcamo] – The Immune System and HIV I. The human body A. Outside or inside? (Fig. 3.1) B. Relationship between host resistance and disease (Fig. 3.2) II. Immune system (Fig. 3.3) A. Trafficking of cells (Fig. 3.4) B. Antigens C. The immune process 1. Phagocytosis (Fig. 3.5) 2. Cell-mediated immunity (Figs. 3.6, 3.7) 3. Antibody-mediated immunity (Fig. 3.9) - reactions carried out by antibody (Fig. 3.10) III. HIV & the Immune System [Healthline 3.3] A. Target cells 1. CD4 + T (T H ) lymphocytes (Fig. 3.11) 2. Macrophages B. Models of pathogenesis 1. “Empty sink” 2. “Turn down the tap” C. Effects of HIV infection on cells 1. T H lymphocytes 2. Macrophages 3. T C lymphocytes [NOTE: Errors in the Weeks text as I indicate below]
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Unformatted text preview: a. Incorrectly refers to CD8 + T lymphocytes as suppressor cells - CD8 + T lymphocytes are cytotoxic T cells as I taught you in class and as described in Talaro text! b. HIV does not replicate in and directly destroy cytoxic T-lymphocytes! c. My best advice is to ignore page 87 and the first paragraph on page 88; and any other page where Weeks describes CD8+ cells as suppressor T lymphocytes and/or says that HIV kills cytotoxic T cells. [Note: Late in HIV disease, CD8 + cytotoxic T lymphocytes do fail to correctly function; but there is no evidence that this is due directly to HIV infecting those cells.] IV. Review A. Matching: 2, 3, 6, 8 10, 12 14, 16 20, 22 25...
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