Unformatted text preview: These engineered cells are then grown in large cultures and produce the pathogen’s protein that is, in turn, harvested, purified, and used as the vaccine. II. AIDS vaccine strategies A. Constraints (Table 9.1, pg. 288) 1. HIV destroys key cells of adaptive immune response 2. HIV exists as provirus, may be ‘dormant’/latent 3. Viral mutation rate B. Types of vaccines tested 1. Subunit/recombinant vaccines, e.g. gp120 (Fig. 9.5) 2. Infectious recombinant virus, based on other animal viruses (viable vector vaccines) C. Prophylactic vaccine clinical trials have not demonstrated protection against HIV infection 1. Therapeutic vaccines for HIV-infected individuals?...
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- Fall '09
- AIDS vaccine, 21st century vaccines, I. General vaccine, viable vector vaccines