Topic 16 WeeksChp9[5th]

Topic 16 WeeksChp9[5th] - These engineered cells are then...

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Chapter 9 [Weeks, Alcamo] – An AIDS Vaccine? I. General vaccine strategies A. Types of vaccines (Fig. 9.2) 1. Whole microbe, inactivated [no viable microbe in the vaccine] 2. Attenuated [pathogen is selected/or modified so that it no longer causes disease, but does replicate in the vaccinated person’s body] B. 20 th , 21 st century vaccines 1. Subunit vaccines – infectious agent is grown in the laboratory, partially purified, and chemically ‘broken’ into parts which when injected as a vaccine induce a protective immune response against the infectious agent 2. Recombinant vaccines – gene encoding protein of pathogen is engineered into another cell (such as yeast or bacteria).
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Unformatted text preview: These engineered cells are then grown in large cultures and produce the pathogen’s protein that is, in turn, harvested, purified, and used as the vaccine. II. AIDS vaccine strategies A. Constraints (Table 9.1, pg. 288) 1. HIV destroys key cells of adaptive immune response 2. HIV exists as provirus, may be ‘dormant’/latent 3. Viral mutation rate B. Types of vaccines tested 1. Subunit/recombinant vaccines, e.g. gp120 (Fig. 9.5) 2. Infectious recombinant virus, based on other animal viruses (viable vector vaccines) C. Prophylactic vaccine clinical trials have not demonstrated protection against HIV infection 1. Therapeutic vaccines for HIV-infected individuals?...
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