Topic 9 Chp12_ChemotherapyOverviewP

Topic 9 Chp12_ChemotherapyOverviewP - TalaroChapter12

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Talaro - Chapter 12 Controlling Microorganisms Inside the Body
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Inside the Body:   Kill the microbe, not the host
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Why do we take antimicrobial drugs? Feel better fast? What do drugs do inside the body? -static drugs (stop replication) -cidal drugs (kill microbe) Are drugs alone enough?
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When do we use a drug? Chemoprophylaxis - attempt to prevent disease - administer pre-exposure Chemotherapy - attempt to treat disease - administer after exposure [symptomatic patient]
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Chemotherapeutic drugs   [Not all drugs are antibiotics] Synthetic drugs Antibiotics Semi-synthetic antibiotics
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Spectrum of activity:  broad vs. narrow Penicillin G > narrow spectrum [inhibits peptidoglycan synthesis] Tetracycline > broad spectrum [interferes w/ protein synthesis]
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Considerations in selecting appropriate  drug treatment * Selective toxicity In vivo  drug stability In vivo
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This note was uploaded on 01/23/2010 for the course BIO 307D taught by Professor Moore during the Fall '09 term at University of Texas at Austin.

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Topic 9 Chp12_ChemotherapyOverviewP - TalaroChapter12

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