Topic 11 Chp15_SpecificImmunityP

Topic 11 Chp15_SpecificImmunityP - TalaroChapter15...

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Talaro – Chapter 15 Specific Immunity, Vaccines
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Host defenses:    Innate (nonspecific) and Adaptive (specific) Immunity Specific Cellular Defenses:   B and T Lymphocytes respond to foreign molecules Specific Resistance
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Features of Adaptive Immunity Acquired  in response to “foreign” invasion - not  innate/inborn [i.e., response  is not preexisting] - Cell involved exist, but they must be activated to  respond Response to specific  ‘invader’ Involves lymphocytes Results in immunologic ‘memory’ - response increases w/ subsequent exposure
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Cells Involved in Specific Immune Response Antigen-presenting cells (APCs) - Dendritic cells* - Macrophages* - B lymphocytes B lymphocytes - Produce antibodies - Generate subpopulation of memory cells T lymphocytes - T helper cells (CD4 + Produce cytokines to ‘signal’ and stimulate actions of other cells  - T cytotoxic cells (CD8 + ) Derived from myeloid progenitor cells  
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Lymphocytes active in Specific Immune  Response Lymphocytes ~ 25 – 33% of WBC
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Stages in Lymphocyte  Development Receptors on cell surface are  central to cell’s immune function. B cells = Ig* 
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This note was uploaded on 01/23/2010 for the course BIO 307D taught by Professor Moore during the Fall '09 term at University of Texas.

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Topic 11 Chp15_SpecificImmunityP - TalaroChapter15...

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